PMP70/ABCD3 Rabbit Monoclonal Antibody (CAB4172)
- SKU:
- CAB4172
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ABC43
- CBAS5
- PMP70
- PXMP1
- ZWS2
- Research Area:
- Cell Biology
Description
| Product Name: | PMP70/ABCD3 Rabbit Monoclonal Antibody |
| SKU: | CAB4172 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 560-659 of human PMP70/ABCD3 (P28288). |
| Sequence: | GWDS VQDW MDVL SGGE KQRM AMAR LFYH KPQF AILD ECTS AVSV DVEG YIYS HCRK VGIT LFTV SHRK SLWK HHEY YLHM DGRG NYEF KQIT EDTV EFGS |
| Tested Applications: | WB IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
| Synonyms: | ZWS2; ABC43; CBAS5; PMP70; PXMP1; PMP70/ABCD3 |
| Positive Sample: | HepG2,A-549,Mouse liver,Mouse kidney,Rat liver |
| Conjugate: | Unconjugated |
| Cellular Localization: | cytosol, mitochondrion, peroxisomal matrix, peroxisome |
| Calculated MW: | 75kDa |
| Observed MW: | 70kDa |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Purification Method: | Affinity purification |
| Gene ID: | 5825 |
| Clone Number: | ARC2131 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using PMP70/ABCD3 Rabbit mAb (CAB4172) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s. |
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