The PMP70 (ABCD3) Polyclonal Antibody (CAB4172) is a vital tool for research involving PMP70, a peroxisomal membrane protein involved in fatty acid beta-oxidation. This antibody, produced in rabbits, exhibits a high reactivity towards human samples and has been validated for use in various applications including Western blot analysis. By specifically binding to the PMP70 protein, this antibody enables researchers to detect and analyze PMP70 expression in different cell types, making it an ideal choice for studies in metabolism, lipid metabolism disorders, and peroxisomal biology.
PMP70, also known as adrenoleukodystrophy protein (ALDP), is essential for the transportation of long-chain fatty acids into peroxisomes for degradation. Dysfunctions in PMP70 have been linked to disorders such as Zellweger syndrome and X-linked adrenoleukodystrophy, highlighting the importance of studying this protein in metabolic and neurological diseases. By understanding the role of PMP70 in fatty acid metabolism, researchers can uncover potential therapeutic targets for treating these conditions and improving patient outcomes.
Product Name:
PMP70/ABCD3 Rabbit Monoclonal Antibody
SKU:
CAB4172
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 560-659 of human PMP70/ABCD3 (P28288).
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
5825
Clone Number:
ARC2131
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PMP70/ABCD3 Rabbit mAb (CAB4172) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
