PMEL Rabbit Polyclonal Antibody (CAB5384)
- SKU:
- CAB5384
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PMEL
- D12S53E
- ME20
- ME20-M
- ME20M
- P1
- P100
- PMEL17
- SI
- SIL
- SILV
- gp100
Frequently bought together:
Description
Product Name: | PMEL Rabbit Polyclonal Antibody |
SKU: | CAB5384 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-430 of human PMEL (NP_008859.1). |
Sequence: | PNTT AGQV PTTE VVGT TPGQ APTA EPSG TTSV QVPT TEVI STAP VQMP TAES TGMT PEKV PVSE VMGT TLAE MSTP EATG MTPA EVSI VVLS GTTA AQVT TTEW VETT ARE |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | P1; SI; SIL; ME20; P100; SILV; HMB45; ME20M; gp100; HMB-45; ME20-M; PMEL17; D12S53E; PMEL |
Positive Sample: | A375 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum membrane, Endosome, Golgi apparatus, Melanosome, Secreted, Single-pass type I membrane protein, multivesicular body. |
Calculated MW: | 70kDa |
Observed MW: | 80kDa/105kDa |
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 6490 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |