The Anti-Plectin Antibody (CAB19743) is a vital tool for researchers studying plectin, a cytoskeletal protein essential for maintaining cell structure and integrity. This polyclonal antibody, produced in rabbits, displays high reactivity with human samples and has been validated for use in various research applications, particularly in Western blot experiments. By binding specifically to the plectin protein, this antibody enables accurate detection and analysis in a wide range of cell types, making it an excellent tool for studies in cell biology and molecular biology.Plectin is known for its crucial role in maintaining the structural organization of cells, as well as its involvement in cellular adhesion and movement.
Understanding the function of plectin is essential for unraveling its contributions to various cellular processes, including cell migration, division, and signaling. As such, this antibody serves as a valuable resource for investigating the roles of plectin in physiological and pathological conditions, such as cancer metastasis, muscle disorders, and skin diseases.Overall, the Anti-Plectin Antibody (CAB19743) offers researchers a reliable and specific tool for studying the intricate functions of plectin in different cellular contexts, providing insights that could lead to the development of novel therapeutic strategies targeting plectin-related diseases.
Product Name:
Plectin Rabbit Monoclonal Antibody
SKU:
CAB19743
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4609 of human Plectin (NP_958782.1).
Cytoplasm, Cytosol, Extracellular exosome, focal adhesion, Intermediate filament cytoskeleton, Mitochondrial outer membrane, Perinuclear region of cytoplasm, Plasma membrane, Z disc
Calculated MW:
532kDa
Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .
Purification Method:
Affinity purification
Gene ID:
5339
Clone Number:
ARC2270
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat brain using Plectin Rabbit mAb (CAB19743) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
