Plectin Rabbit Monoclonal Antibody (CAB19743)
- SKU:
- CAB19743
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EBS1
- EBSMD
- EBSND
- EBSO
- EBSOG
- EBSPA
- HD1
- LGMD2Q
- PCN
- PLEC1
- PLEC1b
- PLTN
Description
| Product Name: | Plectin Rabbit Monoclonal Antibody |
| SKU: | CAB19743 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4609 of human Plectin (NP_958782.1). |
| Sequence: | RTQL ASWS DPTE ETGP VAGI LDTE TLEK VSIT EAMH RNLV DNIT GQRL LEAQ ACTG GIID PSTG ERFP VTDA VNKG LVDK IMVD RINL AQKA FCGF EDPR TKTK MSAA QALK KGWL YYEA GQRF LEVQ YLTG GLIE PDTP GRVP LDEA LQRG TVDA RTAQ KLRD VGAY SKYL TCPK TKLK ISYK DALD RSMV EEGT GLRL LEAA AQST K |
| Tested Applications: | IHC-P ELISA |
| Recommended Dilution: | IHC-P,1:50 - 1:200 |
| Synonyms: | HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17; Plectin |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cytoplasm, Cytosol, Extracellular exosome, focal adhesion, Intermediate filament cytoskeleton, Mitochondrial outer membrane, Perinuclear region of cytoplasm, Plasma membrane, Z disc |
| Calculated MW: | 532kDa |
Plectin is a large, widely expressed protein that crosslinks the intermediate filament and actin cytoskeleton, mechanically stabilizing cells and tissues. Plectin also plays a role in the regulation of actin dynamics and acts as a scaffold for signaling molecules. Plectin is important in the stabilization of hemidesmosomes, crosslinking them to the intermediate filament network. Research studies have shown that mutations in plectin and other genes coding for hemidesmosomal proteins can cause epidermolysis bullosa, a condition manifested by fragile skin and frequent blistering . Plectin modulates signals to PKC through binding and sequestration of RACK1, the receptor for activated C kinase 1 . Plectin is also involved in the regulation of cytokeratin architecture and cell stress response , signaling through the chemokine receptor CXCR4 and regulation of AMP-activated protein kinase (AMPK) activity and signaling in mouse myotubes .
| Purification Method: | Affinity purification |
| Gene ID: | 5339 |
| Clone Number: | ARC2270 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |
 | Immunohistochemistry analysis of paraffin-embedded rat brain using Plectin Rabbit mAb (CAB19743) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. |
Related Products
Plectin Monoclonal Antibody (CAB23479)
SNRPA1 Rabbit Monoclonal Antibody (CAB0647)
NCS1 Rabbit Monoclonal Antibody (CAB0598)
ALDH1A1 Rabbit Monoclonal Antibody (CAB0157)
HDGF Rabbit Monoclonal Antibody (CAB0589)
CARS Rabbit Monoclonal Antibody (CAB0438)
