The PLC beta-3 (PLCB3) Polyclonal Antibody (CAB19738) is a vital tool for researchers studying the role of PLCB3 in cellular signaling pathways. PLCB3 is a member of the phospholipase C (PLC) family, which plays a key role in intracellular signaling by catalyzing the hydrolysis of phosphatidylinositol 4,5-bisphosphate into inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG).This antibody, produced in rabbits, is specifically designed to target PLCB3 in human samples and has been validated for use in Western blot applications. By binding to PLCB3, researchers can detect and analyze the protein in various cell types, providing valuable insights into its function in normal cellular processes and disease states.
PLCB3 is known to be involved in a variety of cellular processes, including cell growth, differentiation, and intracellular signaling. Dysregulation of PLCB3 has been implicated in diseases such as cancer, neurological disorders, and cardiovascular diseases. By studying the expression and activity of PLCB3 using this antibody, researchers can gain a better understanding of its role in these disease pathways and potentially develop targeted therapies for treatment.
Product Name:
PLC beta 3 (PLCB3) Rabbit Monoclonal Antibody
SKU:
CAB19738
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human PLC beta 3 (PLC beta 3 (PLCB3)) (Q01970).
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5331
Clone Number:
ARC2269
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PLC beta 3 (PLC beta 3 (PLCB3)) Rabbit mAb (CAB19738) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
