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Phospho-VANGL2-T78/S79/S82 Monoclonal Antibody (CABP1206)

SKU:
CABP1206
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
VANGL2
LPP1
LTAP
STB1
STBM
STBM1
Research Area:
Cell Biology
$191
Frequently bought together:

Description

Anti-Phospho-VANGL2-T78/S79/S82 Antibody (CABP1206)

The Anti-Phospho-Vangl2 (T78/S79/S82) Antibody (CABP1206) is a powerful tool for researchers studying the phosphorylation of the Vangl2 protein in various cellular processes. Vangl2 is a key component of the planar cell polarity (PCP) pathway, which plays a crucial role in regulating cell polarity and tissue patterning during development.This polyclonal antibody, raised in rabbits, specifically targets the phosphorylated forms of Vangl2 at threonine 78, serine 79, and serine 82. It has been validated for use in Western blot applications and is highly reactive with human samples, offering researchers a reliable and sensitive tool for detecting and analyzing phosphorylated Vangl2 in different cell types.

By facilitating the detection and monitoring of phosphorylated Vangl2, this antibody is essential for investigations into the role of the PCP pathway in various physiological and pathological processes, including embryonic development, tissue homeostasis, and cancer progression. It enables researchers to gain valuable insights into the molecular mechanisms underlying cell polarity and tissue organization, paving the way for the development of targeted therapies for diseases associated with PCP pathway dysregulation.

Product Name:Phospho-VANGL2-T78/S79/S82 Rabbit mAb
Product Code:CABP1206
Size:20uL, 50uL, 100uL
Synonyms:VANGL2, LPP1, LTAP, STB1, STBM, STBM1
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding T78/S79/S82 of human VANGL2
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, NIH/3T3, C6
Immunogen:A phospho specific peptide corresponding to residues surrounding T78/S79/S82 of human VANGL2
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:57216
Uniprot:Q9ULK5
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:59kDa
Observed MW:60KDa
UniProt Protein Function:VANGL2: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Interacts through its C-terminal region with the N- terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3. Belongs to the Vang family.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1q22-q23

Cellular Component: apical plasma membrane; intercellular junction; lateral plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: apical protein localization; establishment of planar polarity; heart looping; neural tube closure; sensory cilium biogenesis

Disease: Neural Tube Defects

NCBI Summary:The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011]
UniProt Code:Q9ULK5
NCBI GenInfo Identifier:38258849
NCBI Gene ID:57216
NCBI Accession:Q9ULK5.2
UniProt Secondary Accession:Q9ULK5,Q5T212, D3DVE9,
UniProt Related Accession:Q9ULK5
Molecular Weight:59,714 Da
NCBI Full Name:Vang-like protein 2
NCBI Synonym Full Names:VANGL planar cell polarity protein 2
NCBI Official Symbol:VANGL2  
NCBI Official Synonym Symbols:LPP1; LTAP; STB1; STBM; STBM1  
NCBI Protein Information:vang-like protein 2
UniProt Protein Name:Vang-like protein 2
UniProt Synonym Protein Names:Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Protein Family:Vang-like protein
UniProt Gene Name:VANGL2  
UniProt Entry Name:VANG2_HUMAN

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