Phospho-TrkA-Y674/675 + TrkB-Y706/707 Rabbit Polyclonal Antibody (CABP0549)
- SKU:
- CABP0549
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NTRK1/NTRK2
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | Phospho-TrkA-Y674/675 + TrkB-Y706/707 Rabbit Polyclonal Antibody |
SKU: | CABP0549 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around Y674 & Y675 of human TrkANTRK1 (NP_001012331.1). |
Sequence: | TDYY RV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | NTRK1/NTRK2; Phospho-TrkA-Y674/675 + TrkB-Y706/707 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | axon, dendrite, early endosome, late endosome, plasma membrane |
Calculated MW: | 35kDa/53-60kDa/77kDa/83-93kDa |
Observed MW: | 140kDa |
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Purification Method: | Affinity purification |
Gene ID: | 4914/4915 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |