The Anti-phospho-TDP-43 (TARDBP S409/S410) Polyclonal Antibody (CABP1241) is a valuable tool for researchers studying TDP-43, a key RNA-binding protein involved in neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This antibody, generated in rabbits, is highly specific for detecting phosphorylated TDP-43 at serine 409 and serine 410 residues in human samples.TDP-43 is known to play a crucial role in RNA processing and regulation, and abnormal phosphorylation of TDP-43 has been implicated in the pathogenesis of ALS and FTD. The CABP1241 antibody is validated for use in Western blot applications, providing researchers with a powerful tool for studying the phosphorylation status of TDP-43 in various biological contexts.
By enabling the detection and analysis of phosphorylated TDP-43, this antibody is valuable for investigations into the mechanisms underlying neurodegenerative diseases. Understanding the role of phosphorylated TDP-43 in disease pathogenesis may lead to the development of novel therapeutic strategies for ALS, FTD, and related neurodegenerative conditions. Researchers working in the fields of neuroscience, neurology, and molecular biology will find the CABP1241 antibody indispensable for their studies.
A synthetic phosphorylated peptide around S409 & S410 of human TDP-43/TARDBP (NP_031401.1).
Sequence:
SKSS GW
Tested Applications:
WBELISADB
Recommended Dilution:
DB,1:500 - 1:1000 WB,1:500 - 1:2000
Synonyms:
ALS10; TDP-43; Phospho-TDP-43/TARDBP-S409/S410
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
45kDa
Observed MW:
Refer to figures
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Purification Method:
Affinity purification
Gene ID:
23435
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Dot-blot analysis of all sorts of peptides using Phospho-TDP-43/TARDB-S409/S410 antibody (CABP1241) at 1:1000 dilution.Exposure time: 1s.
