The Anti-Phospho-Tau (T217) Antibody (CABP1233) is a valuable tool for researchers studying tau phosphorylation, a key event in neurodegenerative diseases such as Alzheimer's. This antibody, raised in rabbits, is highly specific to the T217 phosphorylated form of tau protein and is validated for use in various applications including Western blot and immunohistochemistry.Tau protein is a microtubule-associated protein that plays a crucial role in stabilizing microtubules in neurons. Abnormal phosphorylation of tau protein leads to the formation of neurofibrillary tangles, a hallmark of Alzheimer's disease and other tauopathies.
The Anti-Phospho-Tau (T217) Antibody specifically targets the T217 phosphorylation site, allowing researchers to study the role of this specific phosphorylation event in disease progression.With its high specificity and sensitivity, the Anti-Phospho-Tau (T217) Antibody is an essential tool for studying tau phosphorylation and its implications in neurodegenerative diseases. This antibody is ideal for researchers working in the field of neuroscience and neurodegeneration who are interested in unraveling the mechanisms underlying tau pathology and developing potential therapeutic strategies.
Product Name:
Phospho-Tau-T217 Rabbit Polyclonal Antibody
SKU:
CABP1233
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T217 of human Tau (NP_001190181.1).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Phospho-Tau-T217 Rabbit pAb (CABP1233) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
