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Anti-Phospho-TAK1-T187 Antibody (CABP1222)

SKU:
CABP1222
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CSCF
FMD2
MEKK7
TAK1
TGF1a
MAP3K7
Research Area:
Cell Death
$503
Frequently bought together:

Description

Anti-Phospho-TAK1-T187 Antibody (CABP1222)

The Anti-Phospho-TAK1 (T187) Antibody (CABP1222) is a valuable tool for researchers studying the role of TAK1, a key mediator in the regulation of immune and inflammatory responses. This polyclonal antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the phosphorylated form of TAK1 at threonine 187, this antibody enables the detection and analysis of TAK1 activation in various cell types, providing insights into its involvement in signaling pathways related to immunity and inflammation.

TAK1, also known as transforming growth factor-beta-activated kinase 1, is a crucial regulator of immune responses, playing a central role in the activation of NF-kB and MAPK signaling pathways. Dysregulation of TAK1 activity has been implicated in a variety of diseases, including cancer, autoimmune disorders, and inflammatory conditions. By studying the phosphorylation status of TAK1 at threonine 187, researchers can gain a better understanding of its functional importance in these disease contexts and explore its potential as a therapeutic target for intervention.

Product Name:Phospho-TAK1-T187 Rabbit pAb
Product Code:CABP1222
Size:50uL, 100uL
Synonyms:CSCF, FMD2, MEKK7, TAK1, TGF1a, MAP3K7
Applications:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A phospho specific peptide corresponding to residues surrounding T187 of human MAP3K7.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:293T, NIH/3T3
Immunogen:A phospho specific peptide corresponding to residues surrounding T187 of human MAP3K7.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6885
Uniprot:O43318
Cellular Location:Cell membrane, Cytoplasm, Cytoplasmic side, Peripheral membrane protein
Calculated MW:53kDa/56kDa/64kDa/67kDa
Observed MW:82KDa
UniProt Protein Function:TAK1: a protein kinase of the MLK family. Mediates signal transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. Also activates MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced isoforms have been reported. Three splice variant isoforms have been described.
UniProt Protein Details:

Protein type:Kinase, protein; Protein kinase, TKL; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; TAK1 subfamily

Chromosomal Location of Human Ortholog: 6q15

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; endosome membrane; IkappaB kinase complex; nucleus; cytosol

Molecular Function:MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK activity; activation of MAPKK activity; apoptosis; activation of MAPK activity; stress-activated MAPK cascade; positive regulation of T cell cytokine production; toll-like receptor 3 signaling pathway; T cell receptor signaling pathway; toll-like receptor 10 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; JNK cascade; angiogenesis; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-2 production; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; positive regulation of T cell activation; I-kappaB phosphorylation; neural tube formation

NCBI Summary:The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:O43318
NCBI GenInfo Identifier:12643557
NCBI Gene ID:6885
NCBI Accession:O43318.1
UniProt Secondary Accession:O43318,O43317, O43319, Q5TDN2, Q5TDN3, Q5TDT7, Q9NTR3 Q9NZ70, B2RE27, E1P523,
UniProt Related Accession:O43318
Molecular Weight:67,196 Da
NCBI Full Name:Mitogen-activated protein kinase kinase kinase 7
NCBI Synonym Full Names:mitogen-activated protein kinase kinase kinase 7
NCBI Official Symbol:MAP3K7  
NCBI Official Synonym Symbols:TAK1; MEKK7; TGF1a  
NCBI Protein Information:mitogen-activated protein kinase kinase kinase 7; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1
UniProt Protein Name:Mitogen-activated protein kinase kinase kinase 7
UniProt Synonym Protein Names:Transforming growth factor-beta-activated kinase 1
Protein Family:Mitogen-activated protein kinase kinase kinase
UniProt Gene Name:MAP3K7  
UniProt Entry Name:M3K7_HUMAN

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