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Anti-Phospho-RPS6KA5-T581 Antibody (CABP1197)

SKU:
CABP1197
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
RPS6KA5
MSK1
MSPK1
RLPK
Research Area:
Immunology
$587
Frequently bought together:

Description

Anti-Phospho-RPS6KA5-T581 Antibody (CABP1197)

The Anti-Phospho-RPS6KA5 (T581) Antibody (CABP1197) is a valuable tool for researchers studying the phosphorylation of RPS6KA5, a kinase involved in cell growth and proliferation pathways. This antibody, generated in rabbits, specifically targets the phosphorylated form of RPS6KA5 at threonine 581 and is highly reactive with human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of phosphorylated RPS6KA5 in various cell types.RPS6KA5, also known as RSK2, is a serine/threonine kinase with multiple functions in cell signaling and gene expression. Phosphorylation of RPS6KA5 at threonine 581 has been implicated in the regulation of its kinase activity and downstream signaling cascades.

Understanding the phosphorylation status of RPS6KA5 can provide insights into its biological function and its role in diseases such as cancer and neurological disorders.The Anti-Phospho-RPS6KA5 (T581) Antibody is a valuable tool for researchers investigating the signaling pathways regulated by RPS6KA5 and its potential as a therapeutic target. By enabling the specific detection of phosphorylated RPS6KA5, this antibody can help advance our understanding of the complex mechanisms that govern cell growth and proliferation, opening up new avenues for drug development and personalized medicine.

Product Name:Phospho-RPS6KA5-T581 Rabbit pAb
Product Code:CABP1197
Size:50uL, 100uL
Synonyms:RPS6KA5, MSK1, MSPK1, RLPK
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic phosphorylated peptide around T581 of human RPS6KA5.
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Immunogen:A synthetic phosphorylated peptide around T581 of human RPS6KA5.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:9252
Uniprot:O75582
Cellular Location:Cytoplasm, Nucleus
Calculated MW:61kDa/81kDa/89kDa
Observed MW:Refer to figures
UniProt Protein Function:MSK1: an AGC kinase of the RSK family. Has two kinase domains connected by a regulatory linker region. Enzyme activity requires the presence of both kinase domains. Is phosphorylated and activated by Erk as well as p38 MAPK in response to growth factors and cellular stress.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); AGC group; RSK family; MSK subfamily

Chromosomal Location of Human Ortholog: 14q31-q32.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:ATP binding; histone serine kinase activity (H3-S10 specific); magnesium ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: activation of CREB transcription factor; activation of NF-kappaB transcription factor; axon guidance; epidermal growth factor receptor signaling pathway; histone phosphorylation; inflammatory response; innate immune response; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of cytokine production; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; positive regulation of histone acetylation; positive regulation of histone phosphorylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; regulation of transcription, DNA-dependent; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway

UniProt Code:O75582
NCBI GenInfo Identifier:37999482
NCBI Gene ID:9252
NCBI Accession:O75582.1
UniProt Secondary Accession:O75582,O95316, Q96AF7, B7Z2Y5,
UniProt Related Accession:O75582
Molecular Weight:81,780 Da
NCBI Full Name:Ribosomal protein S6 kinase alpha-5
NCBI Synonym Full Names:ribosomal protein S6 kinase A5
NCBI Official Symbol:RPS6KA5  
NCBI Official Synonym Symbols:MSK1; RLPK; MSPK1  
NCBI Protein Information:ribosomal protein S6 kinase alpha-5
UniProt Protein Name:Ribosomal protein S6 kinase alpha-5
UniProt Synonym Protein Names:90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen- and stress-activated protein kinase 1; RSK-like protein kinase; RSKL
Protein Family:Ribosomal protein S6 kinase
UniProt Gene Name:RPS6KA5  
UniProt Entry Name:KS6A5_HUMAN

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