Phospho-PTEN-S380/T382/383 Polyclonal Antibody (CABP1231)
- SKU:
- CABP1231
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- 10q23del
- BZS
- CWS1
- DEC
- GLM2
- MHAM
- MMAC1
- PTEN1
- TEP1
- PTEN
- PTENbeta
Description
Product Name: | Phospho-PTEN-S380/T382/383 Polyclonal Antibody |
SKU: | CABP1231 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around S380 & T382 & T383 of human PTEN (NP_000305.3). |
Sequence: | YSDT TD |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; PTEN1; 10q23del; PTENbeta; Phospho-PTEN-S380/T382/383 |
Positive Sample: | PC-12 |
Conjugate: | Unconjugated |
Cellular Localization: | apical plasma membrane, cell projection, cytoplasm, cytoplasmic side of plasma membrane, cytosol, dendritic spine, extracellular region, myelin sheath adaxonal region, neuron projection, nucleoplasm, nucleus, plasma membrane, PML body, postsynaptic density |
Calculated MW: | 47kDa |
Observed MW: | 54kDa |
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 5728 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |