Phospho-PKR/EIF2AK2-T446 Rabbit Polyclonal Antibody (CABP1251)
- SKU:
- CABP1251
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- EIF2AK1
- PKR
- PPP1R83
- PRKR
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | Phospho-PKR/EIF2AK2-T446 Rabbit Polyclonal Antibody |
SKU: | CABP1251 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic phosphorylated peptide around T446 of human PKR/EIF2AK2 (NP_002750.1). |
Sequence: | KRTR SK |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IF/ICC,1:50 - 1:200 |
Synonyms: | PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83; Phospho-PKR/EIF2AK2-T446 |
Positive Sample: | NIH/3T3+Calyculin A,NIH/3T3 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, perinuclear region. |
Calculated MW: | 62kDa |
Observed MW: | 68kDa/ |
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses.
Purification Method: | Affinity purification |
Gene ID: | 5610 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |