Phospho-MLKL-S358 Rabbit Polyclonal Antibody (CABP1244)
- SKU:
- CABP1244
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MLKL
- hMLKL
- mixed lineage kinase domain-like protein
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Phospho-MLKL-S358 Rabbit Polyclonal Antibody |
SKU: | CABP1244 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | A synthetic phosphorylated peptide around S358 of human MLKL (NP_689862.1). |
Sequence: | QTSM S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | hMLKL; Phospho-MLKL-S358 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 54kDa |
Observed MW: | 54kDa |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 197259 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |