The Anti-Phospho-IRF7 (S471/472) Antibody (CABP1264) is a valuable tool for researchers studying the phosphorylation of IRF7, a key regulator of the immune response. This antibody is raised in rabbits and is highly reactive with human samples. It is validated for use in Western blot applications, allowing for the detection and analysis of IRF7 phosphorylation in various cell types.IRF7 is a critical transcription factor that plays a central role in the activation of the type I interferon response, a key aspect of the antiviral immune response. Phosphorylation of IRF7 at serine residues 471 and 472 is known to be important for its activation and function.
By targeting these phosphorylation sites, researchers can gain valuable insights into the regulation of IRF7 activity and its impact on the immune response.The Anti-Phospho-IRF7 (S471/472) Antibody is an essential tool for studies in immunology, virology, and cancer research. Understanding the phosphorylation of IRF7 and its effects on immune signaling pathways is crucial for developing new therapies and treatments for infectious diseases, autoimmune disorders, and cancer. By utilizing this antibody, researchers can advance our understanding of IRF7 activation and develop targeted approaches to modulate immune responses for therapeutic benefit.
Product Name:
Phospho-IRF7-S471/472 Rabbit Polyclonal Antibody
SKU:
CABP1264
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic phosphorylated peptide around S471 & S472 of human IRF7 (NP_001563.2).
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses.
Purification Method:
Affinity purification
Gene ID:
3665
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Phospho-IRF7-S471/472 Rabbit pAb (CABP1264) at 1:500 dilution.293T and NIH/3T3 cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
