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Phospho-CGAS-S420 Rabbit Polyclonal Antibody (CABP1228)

SKU:
CABP1228
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
E330016A19Rik
cGAS
€419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-CGAS-S420 Rabbit Polyclonal Antibody
SKU:CABP1228
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Rat
Immunogen:A synthetic phosphorylated peptide around S420 of mouse CGAS (NP_775562.2).
Sequence:FCSY H
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:Mb21d1; E330016A19Rik; Phospho-CGAS-S420
Positive Sample:293T,C6
Conjugate:Unconjugated
Cellular Localization:cytosol, nucleoplasm, nucleus, plasma membrane
Calculated MW:58kDa
Observed MW:62kDa

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:214763
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using Phospho-CGAS-S420 antibody (CABP1228) at 1:1000 dilution.293T and C6 cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.

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