The Anti-Phospho BRD4 (S484/S488) Polyclonal Antibody (CABP1177) is a valuable tool for researchers studying the role of BRD4 in cellular processes and cancer development. This antibody, produced in rabbits, specifically targets phosphorylated residues S484 and S488 on the BRD4 protein, allowing for precise detection and analysis in various cell types.BRD4 is a key regulator of transcription and cell cycle progression, and aberrant activation of BRD4 has been implicated in several types of cancer. The phosphorylation of BRD4 at S484 and S488 has been shown to affect its function, making this antibody an important tool for investigating the mechanisms underlying BRD4-mediated oncogenic processes.
Validated for use in Western blot applications, this antibody provides researchers with the ability to study the phosphorylation status of BRD4 in both normal and diseased tissues. By gaining a better understanding of how phosphorylation impacts BRD4 activity, researchers can potentially identify new therapeutic targets for cancer treatment.
Product Name:
Phospho-BRD4-S484/S488 Rabbit Polyclonal Antibody
SKU:
CABP1177
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S484 & S488 of human BRD4 (NP_490597.1).
The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
23476
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Dot-blot analysis of all sorts of peptides using Phospho-BRD4-S484/S488 antibody (CABP1177) at 1:1000 dilution.
