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Phospho-Beclin 1-Ser90 Rabbit Polyclonal Antibody (CABP1254)

SKU:
CABP1254
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATG6
VPS30
beclin1
Beclin 1
BECN1
beclin-1
Research Area:
Immunology
€419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-Beclin 1-Ser90 Rabbit Polyclonal Antibody
SKU:CABP1254
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic phosphorylated peptide around S90 of human Beclin 1 (NP_003757.1).
Sequence:MMST E
Tested Applications:WB ELISA
Recommended Dilution:WB,1:100 - 1:500
Synonyms:ATG6; VPS30; beclin1; Phospho-Beclin 1-Ser90
Positive Sample:C6
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Cytoplasmic vesicle, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus, Mitochondrion, Mitochondrion membrane, Nucleus, Peripheral membrane protein, autophagosome, trans-Golgi network membrane.
Calculated MW:52kDa
Observed MW:60kDa

This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:8678
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from C6 cells using Phospho-Beclin 1-Ser90 Rabbit pAb (CABP1254) at 1:400 dilution. C6 cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes after serum-starvation overnight.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 60s.

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