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Phospho-ATR-T1989 Rabbit Polyclonal Antibody (CABP1248)

SKU:
CABP1248
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ATR
FCTCS
FRP1
MEC1
SCKL
SCKL1
Research Area:
Epigenetics and Nuclear Signaling
€419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-ATR-T1989 Rabbit Polyclonal Antibody
SKU:CABP1248
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic phosphorylated peptide around T1989 of human ATR (NP_001175.2).
Sequence:NETP P
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:FRP1; MEC1; SCKL; FCTCS; SCKL1; Phospho-ATR-T1989
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:Chromosome, Nucleus, PML body.
Calculated MW:301kDa
Observed MW:300kDa

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

Purification Method:Affinity purification
Gene ID:545
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from HeLa cells, using Phospho-ATR-T1989 Rabbit pAb (CABP1248) at 1:1000 dilution.HeLa cells were treated by Hydroxyurea (4 mM) at 37℃ for 20 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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