The PGC1alpha Polyclonal Antibody (CAB12348) is a valuable tool for researchers studying the PGC1alpha protein, a key regulator of mitochondrial biogenesis and energy metabolism. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.PGC1alpha is a transcriptional coactivator that plays a central role in the control of cellular energy metabolism, making it a critical target for research in the fields of metabolism, obesity, diabetes, and aging. By detecting and analyzing PGC1alpha expression in various cell types, this antibody enables researchers to gain insights into the mechanisms by which PGC1alpha regulates mitochondrial function and energy production.
The importance of PGC1alpha in metabolic homeostasis and its potential implications in metabolic disorders and age-related diseases make it a promising target for therapeutic interventions. Understanding the regulation and function of PGC1alpha may lead to the development of novel treatments for conditions characterized by metabolic dysfunction and mitochondrial impairment.
Product Name:
PGC1α Rabbit Polyclonal Antibody
SKU:
CAB12348
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 610-798 of human PGC1α (NP_037393.1).
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Purification Method:
Affinity purification
Gene ID:
10891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PGC1α Rabbit pAb (CAB12348) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
