PGC1α Rabbit Polyclonal Antibody (CAB12348)
- SKU:
- CAB12348
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PPARGC1A
- LEM6
- PGC-1(alpha)
- PGC-1alpha
- PGC-1v
- PGC1
- PGC1A
- PPARGC1
- PPARG coactivator 1 alpha
- PGC1 alpha
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PGC1α Rabbit Polyclonal Antibody |
SKU: | CAB12348 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 610-798 of human PGC1α (NP_037393.1). |
Sequence: | HRTH RNSP LYVR SRSR SPYS RRPR YDSY EEYQ HERL KREE YRRE YEKR ESER AKQR ERQR QKAI EERR VIYV GKIR PDTT RTEL RDRF EVFG EIEE CTVN LRDD GDSY GFIT YRYT CDAF AALE NGYT LRRS NETD FELY FCGR KQFF KSNY ADLD SNSD DFDP ASTK SKYD SLDF DSLL KEAQ RSLR R |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha); PGC1α |
Positive Sample: | 293T,mouse skeletal muscle,mouse kidney,rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, PML body. |
Calculated MW: | 91kDa |
Observed MW: | 102kDa |
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
Purification Method: | Affinity purification |
Gene ID: | 10891 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |