The Anti-PEX19 Antibody (CAB19237) is a valuable tool for research involving PEX19, a key protein involved in peroxisome biogenesis and maintenance. This polyclonal antibody, raised in rabbits, is highly specific and reacts with human samples, making it suitable for a variety of experimental applications. Validated for use in Western blotting and immunofluorescence, this antibody binds specifically to PEX19, enabling the detection and analysis of this important protein in different cell types.PEX19 is essential for the import of peroxisomal membrane proteins and the assembly of functional peroxisomes, organelles involved in lipid metabolism and detoxification processes.
Dysregulation of peroxisome function has been linked to various genetic disorders and metabolic diseases. Therefore, studying the role of PEX19 in peroxisome biogenesis is crucial for understanding these conditions and developing targeted therapies.Researchers in the fields of cell biology, biochemistry, and genetics will find the Anti-PEX19 Antibody (CAB19237) to be a reliable tool for investigating the function and regulation of PEX19 in cellular processes. Its specificity and versatility make it an ideal choice for studies aiming to unravel the molecular mechanisms underlying peroxisome dysfunction and associated diseases.
Product Name:
PEX19 Rabbit Monoclonal Antibody
SKU:
CAB19237
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PEX19 (P40855).
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5824
Clone Number:
ARC2395
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PEX19 antibody mAb (CAB19237) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
