PEN2/PSENEN Rabbit Monoclonal Antibody (CAB8678)
- SKU:
- CAB8678
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- MDS033
- MSTP064
- PEN-2
- PEN2
Description
Product Name: | PEN2/PSENEN Rabbit Monoclonal Antibody |
SKU: | CAB8678 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-101 of human PEN2/PSENEN (NP_758844.1) |
Sequence: | MNLE RVSN EEKL NLCR KYYL GGFA FLPF LWLV NIFW FFRE AFLV PAYT EQSQ IKGY VWRS AVGF LFWV IVLT SWIT IFQI YRPR WGAL GDYL SFTI PLGT P |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | PEN2; PEN-2; MDS033; ACNINV2; MSTP064; PEN2/PSENEN |
Positive Sample: | 293T,A549,SH-SY5Y,Mouse kidney,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | endoplasmic reticulum, Golgi apparatus, mitochondrion, plasma membrane, presynaptic membrane |
Calculated MW: | 12kDa |
Observed MW: | 14kDa |
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 55851 |
Clone Number: | ARC1779 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |