The PDIA4 Polyclonal Antibody (CAB4326) is a vital tool for researchers studying PDIA4, a protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications.PDIA4, also known as protein disulfide-isomerase A4, is essential for proper protein folding and assembly, ensuring the correct structure and function of proteins within the cell. Dysregulation of PDIA4 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic conditions, highlighting its potential as a therapeutic target.
By utilizing the PDIA4 Polyclonal Antibody, researchers can visualize and quantify PDIA4 levels in different cell types and tissues, offering valuable insights into its role in cellular processes and disease development. This antibody is a valuable asset for studies in cell biology, biochemistry, and molecular biology, providing essential tools for advancing our understanding of PDIA4 function and its implications in human health and disease.
Product Name:
PDIA4 Rabbit Polyclonal Antibody
SKU:
CAB4326
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PDIA4 (NP_004902.1).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly.
Purification Method:
Affinity purification
Gene ID:
9601
Storage Buffer:
Store at -20℃ Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDIA4 Rabbit pAb (CAB4326) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.5s.
