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PDE4A Rabbit Polyclonal Antibody (CAB20162)

SKU:
CAB20162
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
PDE4
DPDE2
PDE46
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:PDE4A Rabbit Polyclonal Antibody
SKU:CAB20162
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 325-410 of human PDE4A (NP_001104777.1).
Sequence:PVPH LQPM SQIT GLKK LMHS NSLN NSNI PRFG VKTD QEEL LAQE LENL NKWG LNIF CVSD YAGG RSLT CIMY MIFQ ERDL LKKF RI
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:PDE4; DPDE2; PDE46; PDE4A
Positive Sample:HeLa,K-562,SH-SY5Y,Mouse testis,Mouse brain,Mouse heart,Rat testis,Rat brain
Conjugate:Unconjugated
Cellular Localization:cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle membrane
Calculated MW:98kDa
Observed MW:80kDa/110kDa

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Purification Method:Affinity purification
Gene ID:5141
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using PDE4A Rabbit pAb (CAB20162) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.

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