The Anti-PDE4A Antibody (CAB20162) is a powerful tool for research on PDE4A, an enzyme involved in the regulation of inflammatory responses. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting PDE4A in human samples, making it an excellent choice for use in Western blot applications. By binding to PDE4A, this antibody enables precise detection and analysis of the enzyme in a variety of cell types, making it a valuable asset for researchers in immunology and pharmacology.PDE4A is a key player in modulating inflammatory signaling pathways, making it a promising target for therapeutic interventions in immune-related diseases such as autoimmune disorders, inflammatory conditions, and certain types of cancer.
By gaining a deeper understanding of PDE4A's role in these diseases, researchers can develop more effective treatments that target this enzyme and its downstream effects on immune responses. The Anti-PDE4A Antibody is an essential tool for advancing research in this critical area of study.
Product Name:
PDE4A Rabbit Polyclonal Antibody
SKU:
CAB20162
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 325-410 of human PDE4A (NP_001104777.1).
cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm, plasma membrane, ruffle membrane
Calculated MW:
98kDa
Observed MW:
80kDa/110kDa
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
5141
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDE4A Rabbit pAb (CAB20162) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
