The Anti-PBRM1 Antibody (CAB0334) is a valuable tool for researchers studying the PBRM1 protein, a key player in chromatin remodeling and transcriptional regulation. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot and immunohistochemistry applications.PBRM1, also known as BAF180, is a subunit of the SWI/SNF chromatin remodeling complex, and alterations in its function have been linked to various cancers, including renal cell carcinoma. The Anti-PBRM1 Antibody allows for the detection and analysis of PBRM1 protein levels in different cell types, making it an essential reagent for studies in cancer biology and epigenetics.
By understanding the role of PBRM1 in chromatin remodeling and gene expression regulation, researchers can gain insights into the mechanisms underlying cancer progression and potentially identify novel therapeutic targets. The Anti-PBRM1 Antibody is a valuable tool for advancing research in oncology and epigenetics.
Product Name:
PBRM1 Rabbit Monoclonal Antibody
SKU:
CAB0334
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 530-680 of human PBRM1 (Q86U86).
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.
Purification Method:
Affinity purification
Gene ID:
55193
Clone Number:
ARC1820
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PBRM1 Rabbit mAb (CAB0334) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
