The Anti-PAR4 Antibody (CAB4983) is a valuable tool for researchers studying the Protease Activated Receptor 4 (PAR4), a cell surface receptor involved in the regulation of platelet activation and function. This polyclonal antibody, produced in rabbits, shows high specificity and reactivity with human samples, making it an ideal choice for experiments such as Western blotting.PAR4 plays a crucial role in mediating platelet response to thrombin, a key mediator of blood coagulation. Dysregulation of PAR4 signaling has been implicated in various cardiovascular diseases, making it a promising target for therapeutic interventions.
By targeting PAR4, researchers can gain insights into the mechanisms underlying thrombosis and potentially develop new treatments for related conditions.With its ability to specifically bind to PAR4, the Anti-PAR4 Antibody enables researchers to detect and analyze the expression of this important receptor in different cell types and tissues. This antibody is a valuable resource for studies in cardiovascular biology, hemostasis, and thrombosis, offering new avenues for understanding and potentially treating related diseases.
Product Name:
PAR4 Rabbit Monoclonal Antibody
SKU:
CAB4983
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 241-340 of human PAR4 (Q96IZ0).
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
Purification Method:
Affinity purification
Gene ID:
5074
Clone Number:
ARC1980
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PAR4 Rabbit mAb (CAB4983) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
