PAR4 Rabbit Monoclonal Antibody (CAB4983)
- SKU:
- CAB4983
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PAR4
- Par-4
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | PAR4 Rabbit Monoclonal Antibody |
SKU: | CAB4983 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 241-340 of human PAR4 (Q96IZ0). |
Sequence: | YSRT DRSG FPRY NRDA NVSG TLVS SSTL EKKI EDLE KEVV RERQ ENLR LVRL MQDK EEMI GKLK EEID LLNR DLDD IEDE NEQL KQEN KTLL KVVG QLTR |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | PAR4; Par-4 |
Positive Sample: | HeLa,SW620,293T,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 37kDa |
Observed MW: | 41kDa |
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
Purification Method: | Affinity purification |
Gene ID: | 5074 |
Clone Number: | ARC1980 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |