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pan-Mono-MethylR (R*GG) Motif Rabbit Polyclonal Antibody (CAB18297)

SKU:
CAB18297
Product Type:
Antibody
Reactivity:
Universal
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:pan-Mono-MethylR (R*GG) Motif Rabbit Polyclonal Antibody
SKU:CAB18297
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence containing monomethylated R.
Tested Applications:WB ELISA DB
Recommended Dilution:DB,1:500 - 1:1000 WB,1:500 - 1:1000
Positive Sample:HCT116,Mouse lung,Mouse liver,Mouse brain,Rat brain
Observed MW:16-120kDa

Arginine methylation is a common posttranslational modification that is found on both histone and non-histone proteins. Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). The most prevalent is omega-NG,NG-dimethylarginine. Here, two methyl groups are placed on one of the terminal nitrogen atoms of the guanidino group; this derivative is commonly referred to as asymmetric dimethylarginine (ADMA). Two other derivatives occur at levels of about 20% to 50% that of ADMA. These include the symmetric dimethylated derivative, where one methyl group is placed on each of the terminal guanidino nitrogens and the monomethylated derivative with a single methyl group on the terminal nitrogen atom . These three derivatives are present on a multitude of distinct protein species in the cytoplasm, nucleus, and organelles of mammalian cells. Methylated arginine residues in proteins are often flanked by one or more glycine residues, but there are many exceptions to this general rule.

Purification Method:Affinity purification
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using pan-Mono-MethylR（R

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