The Anti-p53 (DINP1) Antibody (CAB5952) is a highly specific tool for researchers studying the p53 protein, a critical tumor suppressor involved in regulating cell growth and preventing cancer development. This polyclonal antibody, produced in rabbits, is validated for use in various applications, including Western blotting and immunofluorescence.The p53 protein, also known as the guardian of the genome, plays a central role in controlling cell cycle progression, DNA repair, and apoptosis in response to cellular stress. Mutations in p53 are commonly found in many human cancers, highlighting its importance in maintaining genomic stability and preventing malignant transformation.
By using the Anti-p53 (DINP1) Antibody, researchers can detect and analyze the expression of p53 in different cell types and tissues, shedding light on its function and dysregulation in cancer. This antibody is a valuable tool for investigating the role of p53 in tumorigenesis, guiding the development of targeted therapies and personalized treatment strategies for cancer patients.
Product Name:
p53 DINP1 Rabbit Monoclonal Antibody
SKU:
CAB5952
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human p53 DINP1 (Q96A56).
Hep G2,A-549,BxPC-3,RAW 264.7,C6,Mouse lung,Mouse liver,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
autophagosome, cytoplasmic vesicle, cytosol, nucleoplasm, nucleus, PML body
Calculated MW:
27kDa
Observed MW:
27kDa
Predicted to enable antioxidant activity. Involved in autophagic cell death; positive regulation of autophagy; and positive regulation of transcription, DNA-templated. Located in autophagosome; cytosol; and nucleus.
Purification Method:
Affinity purification
Gene ID:
94241
Clone Number:
ARC2102
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using p53 DINP1 Rabbit mAb (CAB5952) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
