The Anti-p23 (PTGES3) Antibody (CAB5194) is a valuable tool for research involving the p23 protein, also known as PTGES3, which is involved in various cellular processes, including inflammation and cancer. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.p23, a co-chaperone protein, plays a key role in modulating the activity of heat shock proteins and is known to be upregulated in response to cellular stress. Its involvement in various signaling pathways makes it a promising target for studies in cancer biology, inflammation, and other disease contexts.
The Anti-p23 (PTGES3) Antibody binds specifically to the p23 protein, enabling researchers to detect and analyze its expression in different cell types.Understanding the function of p23 is crucial for unraveling its role in disease progression and developing targeted therapies that exploit its signaling pathways. By studying the activity of p23 using this antibody, researchers can gain insights into its functions and potential therapeutic implications in cancer, inflammation, and other pathological conditions.
Product Name:
P23/PTGES3 Rabbit Monoclonal Antibody
SKU:
CAB5194
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human P23/PTGES3 (NP_006592.3).
Rat testis,Rat brain,HeLa,Hep G2,Jurkat,Mouse testis,Mouse brain
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm.
Calculated MW:
19kDa
Observed MW:
23kDa
This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes.
Purification Method:
Affinity purification
Gene ID:
10728
Clone Number:
ARC1986
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using P23/PTGES3 Rabbit mAb (CAB5194) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
