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OTULIN Rabbit Polyclonal Antibody (CAB20489)

SKU:
CAB20489
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GUM
AIPDS
FAM105B
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:OTULIN Rabbit Polyclonal Antibody
SKU:CAB20489
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-352 of human OTULIN (NP_612357.4).
Sequence:EHEE DMYR AADE IEKE KELL IHER GASE PRLS VAPE MDIM DYCK KEWR GNTQ KATC MKMG YEEV SQKF TSIR RVRG DNYC ALRA TLFQ AMSQ AVGL PPWL QDPE LMLL PEKL ISKY NWIK QWKL GLKF DGKN EDLV DKIK ESLT LLRK KWAG LAEM RTAE ARQI ACDE LFTN EAEE YSLY EAVK FLML NRAI ELYN DKEK GKEV PFFS VLLF ARDT SNDP GQLL RNHL NQVG HTGG LEQV EMFL LAYA VRHT IQVY RLSK YNTE EFIT VYPT DPPK DWPV VTLI AEDD RHYN IPVR VCEE TSL
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:GUM; AIPDS; IMD107; FAM105B; OTULIN
Positive Sample:MCF7,Rat liver
Conjugate:Unconjugated
Cellular Localization:cytoplasm, cytosol
Calculated MW:40kDa
Observed MW:45kDa

This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients.

Purification Method:Affinity purification
Gene ID:90268
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of Rat liver, using OTULIN antibody (CAB20489) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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