The Anti-Otulin Antibody (CAB20489) is a crucial tool for researchers studying Otulin, a deubiquitinase enzyme involved in regulating immune signaling pathways. This polyclonal antibody, produced in rabbits, shows high specificity and sensitivity towards Otulin in human samples, making it a reliable choice for Western blot applications.Otulin is known for its role in controlling inflammation and immune responses by removing ubiquitin chains from specific proteins. Dysregulation of Otulin has been linked to various inflammatory conditions and autoimmune diseases.
By targeting Otulin with this antibody, researchers can gain valuable insights into its function and potential therapeutic implications.This antibody is essential for investigating the intricate mechanisms of immune regulation and inflammation, making it a valuable asset for studies in immunology, autoimmune diseases, and inflammatory disorders. Its versatility in detecting Otulin in different cell types makes it an invaluable tool for advancing our understanding of immune system modulation and disease pathogenesis.
Product Name:
OTULIN Rabbit Polyclonal Antibody
SKU:
CAB20489
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-352 of human OTULIN (NP_612357.4).
This gene encodes a member of the peptidase C65 family of ubiquitin isopeptidases. Members of this family remove ubiquitin from proteins. The encoded enzyme specifically recognizes and removes M1(Met1)-linked, or linear, ubiquitin chains from protein substrates. Linear ubiquitin chains are known to regulate the NF-kappa B signaling pathway in the context of immunity and inflammation. Mutations in this gene cause a potentially fatal autoinflammatory syndrome in human patients.
Purification Method:
Affinity purification
Gene ID:
90268
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat liver, using OTULIN antibody (CAB20489) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
