The OSIRE1 Polyclonal Antibody (CAB20585) is a valuable tool for researchers studying the OSIRE1 protein, a key player in immune regulation processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the OSIRE1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies in immunology and cancer research.
OSIRE1, also known as an immune regulatory molecule, functions to modulate immune responses and maintain immune balance. Its role in immune system regulation highlights its importance in research related to diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Investigating the functions of OSIRE1 is crucial in the development of therapies aimed at modulating immune responses in these disease contexts.
Product Name:
OsIRE1 Rabbit Polyclonal Antibody
SKU:
CAB20585
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Oryza sativa
Immunogen:
Recombinant protein of Oryza sativa OsIRE1
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:2000
Synonyms:
IRE1; OsIRE1; OsIre1p; OsJ_24190; OJ1103_E04.109
Positive Sample:
Leaves
Conjugate:
Unconjugated
Calculated MW:
99kDa
Observed MW:
90kDa
Involved in endoplasmic reticulum (ER) stress response. Senses unfolded proteins in the lumen of the ER via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP50 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response (UPR) transcriptional activator, which then induces transcription of UPR target genes, such as luminal-binding protein (BiP) chaperones.
Purification Method:
Affinity purification
Gene ID:
4343198
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various tissues from the japonica rice (Oryza sativa L.) variety Zhonghua 11, using OsIRE1 Rabbit pAb (CAB20585) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 300s.
