ORP150/GRP170/HSP12A Rabbit Monoclonal Antibody (CAB1042)
- SKU:
- CAB1042
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- GRP-170
- Grp170
- HSP12A
- ORP-150
- ORP150
- Research Area:
- Metabolism
Description
Product Name: | ORP150/GRP170/HSP12A Rabbit Monoclonal Antibody |
SKU: | CAB1042 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ORP150/GRP170/HSP12A (Q9Y4L1). |
Sequence: | MADK VRRQ RPRR RVCW ALVA VLLA DLLA LSDT LAVM SVDL GSES MKVA IVKP GVPM EIVL NKES RRKT PVIV TLKE NERF FGDS AASM AIKN PKAT LRYF QHLL GKQA DNPH VALY QARF PEHE LTFD PQRQ TVHF QISS QLQF SPEE VL |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | IMD59; Grp170; HSP12A; ORP150; GRP-170; ORP-150; ORP150/GRP170/HSP12A |
Positive Sample: | HeLa,Hep G2,BxPC-3,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum lumen. |
Calculated MW: | 111kDa |
Observed MW: | 150kDa |
The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 10525 |
Clone Number: | ARC1857 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |