The Anti-Nur77 Antibody (CAB6676) is a polyclonal antibody specifically designed for research involving Nur77, a nuclear receptor protein that plays a key role in regulating gene expression in immune cells. This antibody, raised in rabbits, offers high reactivity with human samples and is validated for use in various applications such as Western blot and immunofluorescence.Nur77, also known as NR4A1, is involved in a variety of cellular processes including apoptosis, inflammation, and metabolism. Its dysregulation has been linked to various diseases including cancer, autoimmune disorders, and metabolic conditions.
Therefore, studying the expression and function of Nur77 is crucial for gaining insights into the molecular mechanisms underlying these diseases.The Anti-Nur77 Antibody (CAB6676) provides researchers with a valuable tool for investigating the role of Nur77 in different biological contexts, ultimately leading to a better understanding of its potential as a therapeutic target for treating various diseases. Its high specificity and sensitivity make it an ideal choice for studies in immunology, oncology, and metabolic disorders.
Product Name:
NUR77 Rabbit Polyclonal Antibody
SKU:
CAB6676
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human NUR77 (NP_002126.2).
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3164
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse testis, using NUR77 Rabbit pAb (CAB6676) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
