The NUP88 Polyclonal Antibody (CAB20729) is specifically designed for research involving NUP88, a protein that plays a critical role in nucleocytoplasmic transport and mRNA export. This antibody, produced in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.NUP88 is a key component of the nuclear pore complex and is involved in transporting molecules in and out of the nucleus. Dysregulation of NUP88 has been linked to various diseases, including cancer, making it a valuable target for research in oncology and cell biology.
By detecting and analyzing NUP88 using this antibody, researchers can gain insight into its function and potential implications in disease progression.Overall, the NUP88 Polyclonal Antibody is a valuable tool for studying NUP88 and its role in cellular processes, offering researchers the opportunity to further uncover its significance in health and disease.
Product Name:
NUP88 Polyclonal Antibody
SKU:
CAB20729
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 502-741 of human NUP88 (NP_002523.2).
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4927
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NUP88 antibody (CAB20729) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
