The Anti-NTRK1/2/3 Antibody (CAB18809) is a valuable tool for researchers studying the NTRK family of proteins, which are involved in cell growth, differentiation, and survival. This polyclonal antibody, raised in rabbits, is highly specific and reactive with human samples. Validated for use in Western blot applications, it targets the NTRK1, NTRK2, and NTRK3 receptors, enabling detection and analysis in a variety of cell types.The NTRK family of proteins, including NTRK1, NTRK2, and NTRK3, play critical roles in neuronal development and function. Dysregulation of these receptors has been implicated in various diseases, including cancer, neurodevelopmental disorders, and chronic pain conditions.
Understanding the expression and activity of NTRK receptors is essential for advancing research in these areas and developing targeted therapies.Whether investigating the role of NTRK receptors in cancer progression, neurodevelopmental disorders, or pain mechanisms, the Anti-NTRK1/2/3 Antibody (CAB18809) offers reliable and specific detection for your research needs. Its versatility and sensitivity make it an ideal tool for studies in oncology, neuroscience, and pain research.
Product Name:
NTRK1/NTRK2/NTRK3 Rabbit Polyclonal Antibody
SKU:
CAB18809
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-796 of human NTRK1/NTRK2/NTRK3 (NP_002520.2).
axon, dendrite, early endosome, late endosome, plasma membrane
Observed MW:
100kDa
Neurotrophic tyrosine kinase (NTRK) is a family of receptor tyrosine kinase.The NTRK gene family contains three members, NTRK1, NTRK2 and NTRK3, which produce TRKA, TRKB and TRKC proteins, respectively.TRK kinases leads to cell differentiation and may play important roles in normal neural functions.Rearrangements in the NTRK genes can result in two genes fusing together and producing altered TRK proteins, which can lead to uncontrolled growth of cancer cells. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer.
Purification Method:
Affinity purification
Gene ID:
4914/4915/4916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NTRK1/NTRK2/NTRK3 Rabbit pAb (CAB18809) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
