NRAS Rabbit Polyclonal Antibody (CAB7566)
- SKU:
- CAB7566
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- NRAS
- ALPS4
- CMNS
- N-ras
- NCMS
- NRAS1
- NS6
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | NRAS Rabbit Polyclonal Antibody |
SKU: | CAB7566 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 90-189 of human NRAS (NP_002515.1). |
Sequence: | FADI NLYR EQIK RVKD SDDV PMVL VGNK CDLP TRTV DTKQ AHEL AKSY GIPF IETS AKTR QGVE DAFY TLVR EIRQ YRMK KLNS SDDG TQGC MGLP CVVM |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | NS6; CMNS; KRAS; NCMS; ALPS4; N-ras; NRAS1; NRAS |
Positive Sample: | 293T,Jurkat,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic side, Golgi apparatus membrane, Lipid-anchor. |
Calculated MW: | 21kDa |
Observed MW: | 21kDa |
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.
Purification Method: | Affinity purification |
Gene ID: | 4893 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |