The NR1D2 Polyclonal Antibody (CAB20447) is a valuable tool for researchers studying NR1D2, a nuclear receptor that plays a crucial role in regulating circadian rhythm and metabolism. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blotting applications. By targeting the NR1D2 protein, this antibody allows for the visualization and analysis of NR1D2 expression in a variety of cell types, making it an essential component of studies in chronobiology and metabolic research.NR1D2, also known as Rev-erb alpha, is a key regulator of the circadian clock and metabolic pathways, influencing processes such as energy metabolism, lipid homeostasis, and glucose regulation.
Its involvement in these fundamental physiological processes positions it as a potential target for therapeutic interventions in metabolic disorders, sleep disorders, and even certain types of cancer. Investigating NR1D2 activity and interactions is essential for advancing our understanding of these health conditions and developing targeted treatments that can modulate NR1D2 function.
Product Name:
NR1D2 Rabbit Polyclonal Antibody
SKU:
CAB20447
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 220-300 of human Rev-erb beta/NR1D2 (NP_005117.3).
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
9975
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Rev-erb beta/NR1D2 antibody (CAB20447) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
