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Anti-NPPC Antibody (CAB20425)

SKU:
CAB20425
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CNP
CNP2
€359
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Description

Product Name:NPPC Rabbit pAb
Product Code:CAB20425
Size:50uL, 100uL
Synonyms:CNP, CNP2
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NPPC (NP_077720.1).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NPPC (NP_077720.1).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4880
Uniprot:P23582
Calculated MW:13kDa
Observed MW:Refer to figures
UniProt Protein Function:NPPC: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Hormone; Secreted

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: extracellular region

Molecular Function:receptor binding

Biological Process: cGMP biosynthetic process; negative regulation of meiotic cell cycle; receptor guanylyl cyclase signaling pathway; regulation of cAMP metabolic process; regulation of cGMP metabolic process

NCBI Summary:This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
UniProt Code:P23582
NCBI GenInfo Identifier:113850
NCBI Gene ID:4880
NCBI Accession:P23582.1
UniProt Secondary Accession:P23582,Q4ZG41,
UniProt Related Accession:P23582
Molecular Weight:13,246 Da
NCBI Full Name:C-type natriuretic peptide
NCBI Synonym Full Names:natriuretic peptide C
NCBI Official Symbol:NPPC  
NCBI Official Synonym Symbols:CNP; CNP2  
NCBI Protein Information:C-type natriuretic peptide
UniProt Protein Name:C-type natriuretic peptide
Protein Family:C-type natriuretic peptide
UniProt Gene Name:NPPC  
UniProt Entry Name:ANFC_HUMAN

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