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Anti-NPPA Antibody (CAB19328)

SKU:
CAB19328
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ANF
ANP
ATFB6
ATRST2
CDD
CDD-ANF
CDP
PND
Research Area:
Cell Biology
$167 - $503
Frequently bought together:

Description

Anti-NPPA Antibody (CAB19328)

The Anti-NPPA Antibody (CAB19328) is a critical tool for researchers studying the NPPA protein, which plays a key role in cardiovascular function. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.NPPA, also known as atrial natriuretic peptide, is a hormone produced by the heart that helps regulate blood pressure and fluid balance. Dysregulation of NPPA has been implicated in various cardiovascular diseases, making it a promising target for therapeutic interventions.

By specifically binding to the NPPA protein, this antibody enables researchers to detect and analyze levels of NPPA in different cell types, facilitating investigations into the pathophysiology of cardiovascular disorders. Understanding the role of NPPA in these conditions is essential for developing new treatments and improving patient outcomes.

Product Name:NPPA Rabbit pAb
Product Code:CAB19328
Size:20uL, 50uL, 100uL
Synonyms:NPPA, ANF, ANP, ATFB6, ATRST2, CDD, CDD-ANF, CDP, PND, NPPA
Applications:IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human NPPA .
Applications:IF
Recommended Dilutions:IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Immunogen:Recombinant protein of human NPPA .
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4878
Uniprot:P01160
Cellular Location:Secreted
Calculated MW:16kDa
Observed MW:Refer to figures
UniProt Protein Function:NPPA: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the natriuretic peptide family.
UniProt Protein Details:

Protein type:Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: extracellular space; mast cell granule; perinuclear region of cytoplasm; extracellular region; nucleus

Molecular Function:neuropeptide hormone activity; peptide hormone receptor binding; receptor binding

Biological Process: cardiac muscle hypertrophy; transcription initiation from RNA polymerase II promoter; cGMP biosynthetic process; negative regulation of systemic arterial blood pressure; positive regulation of heart rate; female pregnancy; response to insulin stimulus; neuropeptide signaling pathway; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; response to hypoxia; gene expression; negative regulation of cell growth; regulation of blood vessel size

Disease: Atrial Standstill 2; Atrial Fibrillation, Familial, 6

NCBI Summary:The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]
UniProt Code:P01160
NCBI GenInfo Identifier:113864
NCBI Gene ID:4878
NCBI Accession:P01160.1
UniProt Secondary Accession:P01160,Q13766, Q5JZE1,
UniProt Related Accession:P01160
Molecular Weight:153
NCBI Full Name:Natriuretic peptides A
NCBI Synonym Full Names:natriuretic peptide A
NCBI Official Symbol:NPPA  
NCBI Official Synonym Symbols:ANF; ANP; PND; ATFB6; ATRST2; CDD-ANF  
NCBI Protein Information:natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A
UniProt Protein Name:Natriuretic peptides A
UniProt Synonym Protein Names:CDD-ANF; PrepronatriodilatinCleaved into the following 2 chains:Cardiodilatin-related peptide; CDP; Atrial natriuretic factor; ANFAlternative name(s):Atrial natriuretic peptide; ANP
UniProt Gene Name:NPPA  
UniProt Entry Name:ANF_HUMAN

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