The Anti-NKX3-1 Antibody (CAB20539) is a valuable tool for researchers studying NKX3-1, a transcription factor known to play a key role in prostate development and prostate cancer. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By binding to the NKX3-1 protein, this antibody enables researchers to detect and analyze NKX3-1 expression in various cell types, facilitating investigations into the molecular mechanisms underlying prostate cancer and other diseases.
NKX3-1 is a critical regulator of prostate cell growth and differentiation, and its dysregulation has been implicated in the pathogenesis of prostate cancer. Research on NKX3-1 has the potential to uncover new therapeutic targets for the treatment of this prevalent disease. By elucidating the functions of NKX3-1, researchers can gain valuable insights into the molecular pathways involved in prostate cancer progression and potentially identify novel strategies for intervention.
Product Name:
NKX3.1 Rabbit Polyclonal Antibody
SKU:
CAB20539
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence within amino acids 1-80 of human NKX3.1 (NP_006158.2).
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
Purification Method:
Affinity purification
Gene ID:
4824
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from LNCaP cells, using NKX3.1 Rabbit pAb (CAB20539) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
