The Anti-NKG2D Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0245) is a specialized antibody designed for research involving NKG2D, a cell surface receptor involved in the activation of natural killer cells and other immune responses. This antibody, derived from rabbit monoclonal sources, is highly specific and reacts strongly with human samples, making it an excellent tool for studying NKG2D in various cell types.The NKG2D receptor plays a crucial role in immune surveillance and anti-tumor responses, making it a key target for cancer immunotherapy research.
By binding to NKG2D, this antibody enables the detection and analysis of this important receptor, allowing researchers to better understand its functions and potential therapeutic applications in cancer and other immune-related diseases.With its high reactivity and specificity, the Anti-NKG2D Chimeric Recombinant Rabbit Monoclonal Antibody is a valuable tool for studies in immunology, oncology, and other fields seeking to unravel the complexities of the immune system and develop novel targeted therapies.
SKU:
HDAB0245
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC287
Synonyms:
NKG2D,CD314,KLRK1,NK cell receptor D
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
