The Anti-NKG2A Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0247) is a cutting-edge tool for immuno-oncology research, specifically targeting the NKG2A receptor, which is involved in regulating immune responses. This antibody, meticulously engineered using advanced technology, offers exceptional specificity and sensitivity for detecting NKG2A in various cell types and tissues.NKG2A is a key immune checkpoint receptor that plays a pivotal role in immune evasion and tumor progression. By targeting NKG2A with this highly specific antibody, researchers can gain invaluable insights into the mechanisms underlying cancer immune escape and develop novel immunotherapies that restore immune surveillance against tumors.
This recombinant rabbit monoclonal antibody is validated for use in various experimental techniques, including immunofluorescence, flow cytometry, and immunohistochemistry. Its superior performance and reliability make it an indispensable tool for investigating the role of NKG2A in cancer biology and exploring new therapeutic strategies for enhancing anti-tumor immune responses.
SKU:
HDAB0247
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC298
Synonyms:
CD159A, NKG2, NKG2A
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.
