The NF-kB2 Polyclonal Antibody (CAB19605) is a valuable tool for research involving NF-kB2, a key transcription factor involved in the regulation of immune and inflammatory responses. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the NF-kB2 protein, it enables researchers to study its expression and activation in a variety of cell types, making it an essential reagent for studies in immunology, cancer research, and inflammation.
NF-kB2 is a crucial mediator of immune and inflammatory pathways, playing a key role in the regulation of cytokine production, cell survival, and immune cell activation. Dysregulation of NF-kB2 signaling has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By understanding the activity and regulation of NF-kB2, researchers can gain insights into the underlying mechanisms of these diseases and potentially identify novel therapeutic targets for intervention.
Product Name:
NF-κB2 Rabbit Monoclonal Antibody
SKU:
CAB19605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 745-877 of human NF-κB2 (Q00653).
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4791
Clone Number:
ARC0084
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using NF-κB2 Rabbit mAb (CAB19605) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
