Neurofilament L Rabbit Monoclonal Antibody (CAB20269)
The Anti-Neurofilament L Antibody (CAB20269) is a valuable tool for researchers studying neurofilament L, a key structural component of neurons involved in maintaining neuronal integrity and function. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in various applications, including immunohistochemistry and Western blotting.Neurofilament L, a major intermediate filament protein in neurons, is essential for axonal growth and maintenance. Abnormalities in neurofilament L expression have been implicated in neurodegenerative diseases such as Alzheimer's and ALS, making it a promising target for diagnostic and therapeutic research.
The Anti-Neurofilament L Antibody enables precise detection and quantification of neurofilament L levels in experimental models and clinical samples, providing valuable insights into neuronal health and pathology. Researchers in the fields of neuroscience, neurology, and neurodegenerative diseases will find the Anti-Neurofilament L Antibody to be an essential tool for studying the role of neurofilament L in neuronal function and dysfunction. Its specificity and sensitivity make it ideal for investigating the intricate mechanisms underlying neurodegenerative disorders and developing novel therapeutic approaches targeting neurofilament L.
Product Name:
Neurofilament L Rabbit Monoclonal Antibody
SKU:
CAB20269
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 60-250 of human Neurofilament L (NP_006149.2).
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Purification Method:
Affinity purification
Gene ID:
4747
Clone Number:
ARC50056
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells using Neurofilament L Rabbit mAb(CAB20269) at 1:100000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time:30s.
