The Neuregulin-3 (NRG3) Monoclonal Antibody (CAB19763) is a valuable tool for researchers studying the role of NRG3, a member of the Neuregulin family known for its involvement in neuronal development and function. This antibody, produced through a hybridoma fusion of mouse myeloma cells with spleen cells from immunized mice, offers high specificity and sensitivity for detecting NRG3 in various experimental settings.NRG3 is a crucial signaling molecule that plays a key role in various biological processes, including neuronal migration, synapse formation, and neurotransmission. Dysregulation of NRG3 has been implicated in neurodevelopmental disorders, schizophrenia, and other neurological conditions.
By targeting NRG3 with this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these disorders and potentially identify novel therapeutic targets.Validated for use in applications such as immunofluorescence, immunohistochemistry, and flow cytometry, the NRG3 Monoclonal Antibody offers versatility and reliability for studies in neuroscience, neurobiology, and psychiatric research. Its ability to specifically recognize NRG3 in samples from various species, including human, mouse, and rat, makes it an indispensable tool for advancing our understanding of the complex functions of this important signaling molecule.
Product Name:
Neuregulin-3 (NRG3) Rabbit Monoclonal Antibody
SKU:
CAB19763
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human Neuregulin-3 (Neuregulin-3 (NRG3)) (P56975).
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
Purification Method:
Affinity purification
Gene ID:
10718
Clone Number:
ARC2289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Neuregulin-3 (Neuregulin-3 (NRG3)) antibody (CAB19763) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
