Neuregulin-3 (NRG3) Rabbit Monoclonal Antibody (CAB19763)
- SKU:
- CAB19763
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- HRG3
- pro-NRG3
Description
Product Name: | Neuregulin-3 (NRG3) Rabbit Monoclonal Antibody |
SKU: | CAB19763 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 600-720 of human Neuregulin-3 (Neuregulin-3 (NRG3)) (P56975). |
Sequence: | IIPS VGLE ETCL QMPG ISEV KSIK WCKN SYSA DVVN VSIP VSDC LIAE QQEV KILL ETVQ EQIR ILTD ARRS EDYE LASV ETED SASE NTAF LPLS PTAK SERE AQFV LRNE IQRD SALT K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | HRG3; pro-NRG3; Neuregulin-3 (NRG3) |
Positive Sample: | SH-SY5Y,U-251MG,C6,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | extracellular region, extracellular space, glutamatergic synapse, plasma membrane |
Calculated MW: | 78kDa |
Observed MW: | 56kDa |
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
Purification Method: | Affinity purification |
Gene ID: | 10718 |
Clone Number: | ARC2289 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |